By Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)
The e-book comprises unique articles and experiences provided on the sixth overseas iciness convention on Neurodegeneration, held from November 20–23, 1997 in Kitzbuhel/Austria. the purpose of this convention was once to provide and speak about fresh information at the interface among neuroimmunology and neurodegeneration, specifically susceptibility to autoimmune and neurodegenerative methods, neuroprotection and restorative therapy techniques. those matters have been mentioned within the mild of contemporary advancements in a number of sclerosis, Parkinson’s disorder, amyotrophic lateral sclerosis, Huntington’s sickness and multisystem atrophy. The articles spotlight subject matters, that are rather fascinating for the clinician and the neuroscientist. many of the neuroprotective ideas have already been built or are at the moment clinically investigated. The neuroprotective position of deep mind stimulation, antiglutamatergic remedy and apomorphine may be validated in medical experiences within the close to destiny. this is often additionally the case for destiny healing methods to recovery of the broken frightened approach, reminiscent of somatic gene treatment, implantation of genetically transformed cell-lines and medically managed and directed improvement of embryonic cells. The convention highlighted the position of the glia, which turns out to play a key position, either in frequently as neuroimmunological and neurodegenerative problems categorized illnesses, as indicated above. the subjects mentioned within the publication are major for fresh advancements in scientific neurology and neuroscience, as proven within the present literature and at foreign congresses.
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Extra resources for Advances in Research on Neurodegeneration: Volume 6
Mov Disord 13: 46-51 Kreider M, Knox S, Gardiner D, Wheadon D (1996) A multicenter double-blind study of ropinirole as an adjunct to L-dopa in Parkinson's disease. Neurology 46: 475 Larsen JP, Brunt E, Korczyn AD, Nagy Z, Poewe W, Ruggieri S and the 053 Study Group (1998) Ropinirole is effective in long-term treatment of patients with early Parkinson's disease. Neurology 50: 277-278 Lieberman A, Imke S, Muenter M, Wheeler K, Ahlskog JE, Matsumoto JY, Maraganore DM, Wright KF, Schoenfelder J (1993) Multicenter study of cabergoline, a longacting dopamine receptor agonist, in Parkinson's disease patients with fluctuating responses to levodopa/carbidopa.
Advanced Parkinson's disease In this situation, the dopamine agonist is adjuncted to levodopa when this last drug has already induced motor complications, generally motor fluctuations. Several trials using a quite similar design have recently shown that cabergoline, pramipexole and ropinirole are all doing better than placebo in patients with Parkinson's disease suffering from the wearing-off phenomenon. 5mg/d, significantly improved the mean score of UPDRS part II (22% reduction with pramipexole vs.
The initial pilot studies assessing this question with the "older" agonists all suffered from evident methodological shortcomings (Factor and Weiner, 1993). However, recent animal experiments have shown that, like in humans, some agonists, like ropinirole and bromocriptine, elicit comparable dyskinesia than levodopa once levodopa priming has occured, while they have a marked lesser tendency than levodopa to produce dyskinesia while similarly improving motor performance in drugnaive MPTP-treated monkeys.
Advances in Research on Neurodegeneration: Volume 6 by Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)